Children's Hospital Medical Center

Description

We provide streamlined service from DNA to founder animals. We use the latest genome-editing technologies, such as CRISPR-Cas9 and TALEN, to generate animals carrying multiple knockout or knock-in alleles in a highly efficient and time-saving fashion. We also provide conventional approaches to generate transgenic mice by pronuclear microinjection and chimeric mice using embryonic stem cells. The facility has also undertaken several new initiatives including implementation of a fast CRISPR-Cas9 genetic screen system and generation of genetically modified rats.

We provide researchers with access to state of the art 275-channel whole head human magnetometry with data acquisition rates up to 12 kHz per channel. The system can also do simultaneous EEG recordings. We provide orientation to data collection with the magnetometer including a stimulus presentation computer for auditory, visual, somatosensory stimuli, and bimanual 5 finger response pads for task-based studies.

Cincinnati Children’s Research Foundation is dedicated to advancing basic, translational, clinical and outcomes-based research. Why choose our facilities for your research? We can provide you with cutting-edge, cost-effective technology and data analysis that would be unattainable on an individual research basis. Our fee-for-service program also offers unique studies that you can’t find anywhere else.

The Translational Core Labs include The Viral Vector Core, The Vector Production Facility, The Stem Cell Processing Lab, The Cell Manipulations Lab and the Translational Trial Development and Support Lab (TTDSL). We specialize in the translation and scale up of gene therapy and cell therapy including iPSC and HEK in addition to the patient testing associated with these trials.

We will train you to use state-of-the-art confocal microscopes for your research. We provide access to confocal microscopes, deconvolution microscopes and computer analysis workstations. Once you’ve been trained by our staff, you may access our facilities 24 hours a day.

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