Cosmetic Ingredient Review

Description

The CIR Procedures established an Expert Panel to set priorities and review and assess ingredient safety data. The seven CIR Expert Panel voting members include physicians and scientists who have been publicly nominated by consumer, scientific and medical groups, government agencies and industry. Three liaison members serve as non-voting members representing the U.S. Food & Drug Administration (FDA), Consumer Federation of America and Cosmetic, Toiletry & Fragrance Association (CTFA). By uniting industry, consumers and government, the Expert Panel creates a unique environment for discussions affecting public safety. Working on the high priority ingredients, CIR staff conduct extensive literature searches, compile data and prepare draft reports. CIR staff organize the literature into chemistry, including physical properties and manufacture; use, including cosmetic and non-cosmetic; general biology, including absorption, distribution, and metabolism; animal toxicology, including acute, short-term, subchronic, and chronic studies, as well as dermal irritation and sensitization; and a clinical assessment, which may include epidemiology studies along with classic repeat insult patch tests. In vitro test data are also gathered and incorporated into the review. If the open, scientific literature contains insufficient information, the Panel will call on industry or other interested parties to undertake specific studies or to provide previously unpublished data...

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