Expression Systems, LLC

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Description

Expression Systems LLC is dedicated to supplying and servicing the commercial Insect Cell Culture markets with innovative media formulations, complimentary products and contract services. Our mission is to maximize insect cell expression capabilities, with a target yield that is greater than 1 gram per liter. Expression Systems Formula, ESF 921, is the company's flagship product. ESF 921 medium is widely recognized as the industry's standard for applications such as high throughput gene expression for drug discovery. ESF 921 medium works well for a multitude of insect cell lines; whether you are using Lepidopteran cells such as Spodoptera frugiperda's Sf9 or Sf21, Trichoplusia ni (e.g. Tni PRO™), Estima acrea (Ea4) or Dipteran cells (e.g., Drosophila S2). Each batch of ESF 921 is quality tested to insure consistency from lot to lot. Unique to Expression Systems is the Animal Free Formulation for insect cell culture. This complete medium is 100% free of any animal components or animal-derived components. It is compatible with a variety of insect cell lines. ESF AF is the logical choice for manufacturing under cGMP/FDA regulatory compliance. It is the most technologically advanced formulation available and has an active Drug Master File on record with US FDA. Other products developed by ES to enhance insect culture expression include: transfection medium for better cellular DNA uptake, production boost additives for increasing expression, custom formulation for Selenomethionine protein labeling and baculovirus titer kits. ES offers a variety of contract services that includes; high throughput gene expression program (from transfection to scale up optimization) and a high throughput baculovirus titering service. ES has an active development program for designing new DNA vectors. ES has an ongoing collaboration to develop a new type of bioreactor for scale up manufacturing. For many years Expression Systems has been successfully contracting to produce a variety of proteins for our clientele. This experience, combined with our animal free medium and our unique Tni PRO™ cell line provides Expression Systems with a very competitive platform to base a future GMP contract manufacturing business.

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