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Description
The concept of developing a robust and high-fidelity thermostable polymerase system for DNA primer extension was introduced in a 1987 report by G. F. Hong (1), a pioneer in nucleic acid research (2). Our team, composed of a group of cell biologists, pathologists and virologists, succeeded in transforming this concept into practice a few years ago. Now we are introducing this enzymatic repeated cycle primer extension technology to the world upon expiration of the PCR process patents formerly owned by Hoffmann-La Roche.