Osel Inc

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Description

The healthy female urogenital tract is densely populated with commensal bacteria, primarily certain Lactobacillus species, that play an important role in protecting the host from infection. Disruption of the Lactobacillus-dominated microbial flora can lead to abnormal vaginal microbial communities associated with bacterial vaginosis (BV), and an increased incidence of urinary tract infection (UTI). In addition, epidemiological studies suggest that the normal vaginal microbial ecosystem may play a critical role in reducing the risk of sexually transmitted infections, including human immunodeficiency virus type 1 (HIV-1). These observations have provided the rationale for using appropriate Lactobacillus species to reduce the risk of infection by preserving or restoring the normal vaginal microflora. Our lead product candidate, LACTIN-V vaginal capsule, contains the lactic acid and hydrogen peroxide producing bacterium Lactobacillus crispatus, a naturally occurring member of the protective urogenital microflora.

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