SmartFlow Technologies

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Description

When a TFF cassette or hollow fiber does not encounter the cleaning agent in all portions of the membrane, issues can arise such that customers see a higher incidence of cleaning criteria being outside an acceptable range. SmartFlow Technologies offers the OPTISEP module with its patented design to help alleviate these contamination issues. With our unique fluid dynamic properties, the entire surface area of the membrane is treated with the cleaning agent, and when utilizing one of our specialized skids , customers see minimal dead legs and hold-up volume during cleaning.

Mammalian cells have long been a major producer of therapeutic protein in the biotechnology industry. As the batch sizes and titer of mammalian cell products have increased, the downstream processing of mammalian cell cultures has caused a bottleneck in the production of these proteins. One major step that has caused a problem with processing of mammalian cells is the cell harvest based on their frequency to lyse during purification, causing a greater amount of debris in downstream purification steps.

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